Strain Differences in N-Butyl-N-(4-hydroxybutyl)nitrosamine Bladder Carcinogenesis in Rats
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چکیده
منابع مشابه
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...
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http://tpx.sagepub.com/content/27/6/645 The online version of this article can be found at: DOI: 10.1177/019262339902700606 1999 27: 645 Toxicol Pathol Cohen Kumiko Ogawa, Margaret St. John, Maria Luiza De Oliveira, Lora Arnold, Tomoyuki Shirai, Tung-Tien Sun and Samuel M. N-Butyl-N-(4-Hydroxybutyl)Nitrosamine in Rats and Mice Comparison of Uroplakin Expression During Urothelial Carcinogenesis ...
متن کاملThe interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice
The bladder is an important organ for the storage of excreted water and metabolites. If metabolites with carcinogenic characteristics are present in urine, the urothelial lining of the bladder could be damaged and genetically altered. In this study, we analyzed the interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) on mouse bladder carcinogenesis. Our previous study found th...
متن کاملStrong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
The tumor-promoting effect of uracil-induced calculi on rat urinary bladder carcinogenesis was investigated in male F344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Since uracil-induced calculi and papillomatosis of the bladder are reversible, uracil was given for a limited period after the treatment with BBN. Animals were given 0.05% BBN in their drinking water for 4 wk a...
متن کاملLack of enhancing effect of mucosal regeneration following ulceration of the urinary bladder on N-butyl-N-(4-hydroxybutyl)nitrosamine carcinogenesis in rats.
The potential enhancing effects of the regeneration response of the urothelium following ulceration of the bladder mucosa on N-butyl-N-(4-hydroxybutyl)nitrosamine carcinogenesis were examined in male Fischer rats. The carcinogen was administered in the drinking water at a concentration of 0.05% for 2 weeks. Ulceration was performed by a freezing technique 24 hr before the administration or 24 h...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1988
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1988.tb01613.x